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Inventi Impact: Genetics

Articles

  • Inventi:hsc/41/12
    LONG-TERM OUTCOME AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION WITH ADEQUATE PERIPHERAL BLOOD STEM CELL MOBILIZATION USING PLERIXAFOR AND G-CSF IN POORMOBILIZER LYMPHOMA ANDMYELOMA PATIENTS
    30-Sep-2012 Research 2012 : October - December
    Jan S Moreb, Donya Salmasinia, Jack Hsu, Wei Hou,\r\nChristina Cline, Emma Rosenau

    Poor peripheral blood stem cell (PBSC) mobilization predicts worse outcome for myeloma and lymphoma patients post\r\nautologous stem cell transplant (ASCT). We hypothesize that PBSC harvest using plerixafor and G-CSF in poor mobilizers may\r\nimprove long-termoutcome.We retrospectively analyzed the data on patients who had second PBSC mobilization using plerixafor\r\nand G-CSF as a rescue. Nine lymphoma and 8 multiple myeloma (MM) patients received the drug. A control group of 25MMand\r\nlymphoma patients who were good mobilizers with G-CSF only was used for comparison. Sixteen of the 17 poor mobilizers\r\nproceeded to ASCT, and one MM patient had tandem transplants. Length of hospital stay, infection incidence, granulocyte\r\nengraftment, and long-term hematopoietic recovery were not significantly different between the two groups. In conclusion, all\r\npoor mobilizers were able to obtain adequate stem cells transplant dose and had similar transplant course and long-term outcome\r\nto that of the control good mobilizers group.

    How to Cite this Article
    CC Compliant Citation: Jan S. Moreb, Donya Salmasinia, Jack Hsu,\r\nWei Hou, Christina Cline, and Emma Rosenau, â??Long-Term\r\nOutcome after Autologous Stem Cell Transplantation with\r\nAdequate Peripheral Blood Stem Cell Mobilization Using Plerixafor\r\nand G-CSF in Poor Mobilizer Lymphoma and Myeloma Patients,â?\r\nAdvances in Hematology, vol. 2011, Article ID 517561, 8 pages,\r\n2011. doi:10.1155/2011/517561.
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